Health Library

B-cell leukemia/lymphoma panel

B lymphocyte cell surface markers; Flow cytometry - leukemia/lymphoma immunophenotyping

B-cell leukemia/lymphoma panel is a blood test that looks for certain proteins on the surface of white blood cells called B-lymphocytes. The proteins are markers that may help diagnose leukemia or lymphoma.

Images

I Would Like to Learn About:

How the Test is Performed

A blood sample is needed.

In some cases, white blood cells are removed during a bone marrow biopsy. The sample may also be taken during a lymph node biopsy or other biopsy when lymphoma is suspected.

The blood sample is sent to a laboratory, where a laboratory specialist checks the cell type and characteristics. This procedure is called immunophenotyping. The test is often done using a technique called flow cytometry.

How to Prepare for the Test

No special preparation is usually necessary.

How the Test will Feel

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.

Why the Test is Performed

This test may be done for the following reasons:

• When other tests (such as a blood smear) show signs of abnormal white blood cells
• When leukemia or lymphoma is suspected
• To find out the type of leukemia or lymphoma

What Abnormal Results Mean

Abnormal results usually indicate either:

• B-cell lymphocytic leukemia
• Lymphoma

Risks

There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight, but may include:

• Excessive bleeding
• Fainting or feeling lightheaded
• Multiple punctures to locate veins
• Hematoma (blood accumulating under the skin)
• Infection (a slight risk any time the skin is broken)

Related Information

References

Connors JM, Savage KJ. Hodgkin lymphoma. In: Goldman L, Cooney K, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 172.

Vose JM, Armitage JO. Non-Hodgkin lymphomas. In: Goldman L, Cooney K, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 171.

Walter RB, Appelbaum FR. The acute leukemias. In: Goldman L, Cooney K, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 168.

Review Date: 3/31/2024  

Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

A.D.A.M., Inc. is accredited by URAC, for Health Content Provider (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics. This site complies with the HONcode standard for trustworthy health information: verify here.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- 2024 A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.