Health Library

Quantitative Bence-Jones protein test

Immunoglobulin light chains - urine; Urine Bence-Jones protein

This test measures the level of abnormal proteins called Bence-Jones proteins in the urine.

Images

I Would Like to Learn About:

How the Test is Performed

A clean-catch urine sample is needed. The clean-catch method is used to prevent germs from the penis or vagina from getting into a urine sample. To collect your urine, the health care provider may give you a special clean-catch kit that contains a cleansing solution and sterile wipes. Follow instructions exactly so that the results are accurate.

The sample is sent to the lab. There are many methods used to detect Bence-Jones proteins. One method, called immunoelectrophoresis, is the most accurate.

How the Test will Feel

The test involves only normal urination, and there is no discomfort.

Why the Test is Performed

Bence-Jones proteins are a part of regular antibodies called light chains. These proteins are not normally in urine. Sometimes, when your body makes too many antibodies, the level of light chains also rises. Bence-Jones proteins are small enough to be filtered out by the kidneys. The proteins then spill into the urine.

Your provider may order this test:

• To diagnose conditions that lead to protein in the urine
• If you have a lot of protein in your urine
• If you have signs of a blood cancer called multiple myeloma

Normal Results

A normal result means no Bence-Jones proteins are found in your urine.

What Abnormal Results Mean

Bence-Jones proteins are rarely found in urine. If they are, it is usually associated with multiple myeloma.

An abnormal result may also be due to:

• An abnormal buildup of proteins in tissues and organs (amyloidosis)
• Blood cancer called chronic lymphocytic leukemia
• Lymph system cancer (lymphoma)
• Buildup in the blood of a protein called M-protein (monoclonal gammopathy of unknown significance; MGUS)
• Chronic renal failure

Risks

There are no risks with this test.

Related Information

References

Chernecky CC, Berger BJ. Protein electrophoresis - urine. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:920-922.

Riley RS, McPherson RA. Basic examination of urine. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 29.

Rajkumar SV, Dispenzieri A. Multiple myeloma and related disorders. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 101.

Review Date: 4/29/2022  

Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

A.D.A.M., Inc. is accredited by URAC, for Health Content Provider (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics. This site complies with the HONcode standard for trustworthy health information: verify here.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- 2024 A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.