Drug Notes - Didanosine (By mouth) | Lima Memorial Health System

Didanosine (By mouth)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to didanosine.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Didanosine is taken together with other medicines to treat HIV infection. Take all other medicines your doctor has prescribed at the right time each day.
Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.
It is best to take this medicine on an empty stomach. The oral liquid should be taken at least 30 minutes before or 2 hours after you eat.
Delayed-release capsule: Swallow the capsule whole. Do not crush, chew, break, or open it.
Oral liquid: Shake the bottle before using. Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
Storage instructions:
- Delayed-release capsule: Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Oral liquid: Store the liquid in the refrigerator. Throw away any unused liquid medicine after 30 days.

Do not use this medicine if you are also using allopurinol, ribavirin, or stavudine.
Some medicines can affect how didanosine works. Tell your doctor if you are using any of the following:
- Delavirdine, ganciclovir, hydroxyurea, indinavir, methadone, nelfinavir, tenofovir
- Antacids containing aluminum or magnesium
- Medicine to treat an infection (including ciprofloxacin, tetracycline)
If you are also using itraconazole or ketoconazole, take them at least 2 hours before using this medicine.
Do not drink alcohol while you are using this medicine.

Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, pancreas problems, or a history of nerve problems. Tell your doctor if you drink alcohol.
Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.
This medicine may cause the following problems:
- Pancreatitis (swelling of the pancreas)
- Lactic acidosis (too much acid in the blood)
- Liver problems, including portal hypertension (high blood pressure in the portal vein of the liver)
- Peripheral neuropathy (a nerve problem)
- Eye or vision problems
Always practice safe sex, even if your partner also has HIV. If you stop taking this medicine or do not take it as prescribed, you may spread HIV to others. Do not reuse or share needles, or other items, that may have blood or body fluids on them.
Your immune system may get stronger when you start taking HIV medicines. This could cause a hidden infection in your body to become active. Tell your doctor right away if you notice any changes in your health.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor may also want you to have your eyes checked regularly by an eye doctor.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Eye pain, blurred vision, dry eyes
Fast or troubled breathing, severe weakness, tiredness, confusion
Loss of fat from the arms, legs, or face
Numbness, tingling, or burning pain in your hands, arms, legs, or feet
Slow or uneven heartbeat, dizziness, fainting, or lightheadedness
Sudden and severe stomach pain, fever

Last Updated: 9/6/2024