Health Library

Chlordiazepoxide/amitriptyline (By mouth)

Amitriptyline Hydrochloride (am-i-TRIP-ti-leen hye-droe-KLOR-ide), Chlordiazepoxide (klor-dye-az-e-POX-ide)

Treats depression caused by anxiety. This medicine is a combination of a benzodiazepine and a tricyclic antidepressant (TCA).

Brand Name(s):

Limbitrol DS

When This Medicine Should Not Be Used:

How to Use This Medicine:

Tablet

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use this medicine if you have used an MAO inhibitor within the past 14 days.
• Some foods and medicines can affect how this medicine works. Tell your doctor if you are using any of the following:
  • Cimetidine, guanethidine, topiramate
  • Medicine for heart rhythm problem (including flecainide, propafenone, quinidine)
  • Other medicine to treat depression (including fluoxetine, paroxetine, sertraline)
  • Phenothiazine medicine (including chlorpromazine, prochlorperazine, promethazine, thioridazine)
• Do not drink alcohol while you are using this medicine.
• Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or planning to become pregnant. Using this medicine during the later part of a pregnancy may cause problems in your newborn baby (including sedation or withdrawal symptoms). Tell your doctor right away if you think you have become pregnant.
• Tell your doctor if you are breastfeeding or planning to breastfeed. This medicine passes into your breast milk and may cause problems in your baby. Talk to your doctor about the best way to feed your baby.
• Tell your doctor if you have kidney disease, liver disease, heart or blood vessel disease, an overactive thyroid, or a history of glaucoma, seizures, or trouble urinating.
• This medicine may cause the following problems:
  • Increased risk of overdose, which can be life-threatening
  • Respiratory depression (serious breathing problem that can be life-threatening), especially when used with narcotic pain medicines
  • Increased risk of suicidal thoughts or behavior
  • Eye or vision problems, including increased pressure in the eye
  • Changes in heart rhythm (including arrhythmia)
  • Heart attack or stroke
• This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
• Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.
• Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
• This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blue lips, fingernails, or skin
• Blurred vision, change or loss of consciousness, dizziness, faintness, lightheadedness, problems with coordination or walking, unusual drowsiness
• Change in how much or how often you urinate, trouble urinating
• Changes in behavior, unusual thoughts of hurting yourself or others, trouble sleeping
• Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating, faintness
• Fast, pounding, or uneven heartbeat
• Seizures or tremors

If you notice these less serious side effects, talk with your doctor:

• Constipation
• Dizziness or drowsiness
• Dry mouth

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024