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Cefoperazone (By injection)

Cefoperazone (sef-oh-PER-a-zone)

Treats infections caused by bacteria. This medicine is a cephalosporin antibiotic.

Brand Name(s):

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given as a shot into a muscle or through a needle placed into a vein.
• A nurse or other health provider will give you this medicine.
• You should receive every dose that is prescribed to clear up your infection, even if you feel better after the first few doses.
• Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how cefoperazone works. Tell your doctor if you are taking a blood thinner (including warfarin) or other antibiotics (including aminoglycosides).
• Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, bleeding problems, malabsorption problems (including cystic fibrosis), poor nutrition status, or a history of alcohol abuse, or stomach or bowel disease, including colitis. Tell your doctor if you had an allergic reaction to penicillin.
• This medicine may cause the following problems:
  • Serious skin reactions (including Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis)
  • Increased risk of bleeding
• This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine. Check with your doctor right away if the diarrhea continues. Diarrhea may occur 2 months or more after you stop receiving this medicine.
• Tell your doctor or dentist that you are receiving this medicine. It may affect the results of certain medical tests.
• Call your doctor if your symptoms do not improve or if they get worse.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, red skin rash
• Severe diarrhea (watery or bloody), vomiting, or stomach pain
• Swelling of the face, throat, or lips
• Trouble breathing, tiredness, yellow skin or eyes
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Pain, itching, burning, swelling, or a lump under your skin where the needle was placed or shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024