Health Library

Midazolam (By injection)

Midazolam (MID-ay-zoe-lam)

Treats status epilepticus (continuous seizures). Also used to relieve anxiety before surgery.

Brand Name(s):

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
• A nurse or other health provider will give you this medicine.
• After you receive a shot of this medicine, your doctor will watch you closely to make sure it is working properly and to check for unwanted effects.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how midazolam works. Tell your doctor if you are using cimetidine, diltiazem, erythromycin, itraconazole, ketoconazole, or verapamil.
• Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are also using droperidol, fentanyl, meperidine, morphine, or secobarbital.
• Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or planning to become pregnant. Using this medicine during the later part of a pregnancy may cause problems in your newborn baby (including sedation or withdrawal symptoms). Tell your doctor right away if you think you have become pregnant.
• Tell your doctor if you are breastfeeding or planning to breastfeed. This medicine passes into your breast milk and may cause problems in your baby. Talk to your doctor about the best way to feed your baby.
• Tell your doctor if you have kidney disease, heart failure, lung or breathing problems (including COPD), low blood pressure, eye or vision problems (including glaucoma), or a history of alcohol or drug abuse.
• This medicine may cause the following problems:
  • Increased risk of overdose, which can be life-threatening
  • Respiratory depression (serious breathing problem that can be life-threatening), especially when used with narcotic pain medicines
  • Low blood pressure
  • Eye or vision problems, including increased pressure in the eye
• This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
• Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Agitation, tremor, restlessness, jerky muscle movement you cannot control (often in your face, tongue, or jaw)
• Blue lips, fingernails, or skin, trouble breathing, chest pain
• Blurred vision or other change in vision, eye pain
• Change or loss of consciousness, confusion, dizziness, faintness, lightheadedness, problems with coordination or walking, unusual drowsiness
• Changes in mood or behavior, thoughts or attempts of hurting yourself
• Severe drowsiness or weakness, slow heartbeat

If you notice these less serious side effects, talk with your doctor:

• Pain, itching, burning, swelling, or a lump where the shot is given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024