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Nateglinide (By mouth)

Nateglinide (na-te-GLYE-nide)

Treats type 2 diabetes.

Brand Name(s):

When This Medicine Should Not Be Used:

How to Use This Medicine:

Tablet

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
• Take this medicine 1 to 30 minutes before a meal. If you skip a meal, then you should also skip your dose of nateglinide.
• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some foods and medicines can affect how nateglinide works. Tell your doctor if you are using any of the following:
  • Amiodarone, clonidine, fluconazole, glucomannan, guanethidine, gymnema sylvestre, lanreotide, methandrostenolone, miconazole, octreotide, oxandrolone, phenytoin, reserpine, rifampin, somatropin, sulfinpyrazone, St John's wort, thioctic acid, voriconazole
  • Blood pressure medicine (including beta-blockers)
  • Diuretic (water pill)
  • MAO inhibitor
  • NSAID pain or arthritis medicine (including, aspirin, celecoxib, ibuprofen, naproxen)
  • Other oral diabetes medicine
  • Steroid medicine
  • Thyroid medicine
• Tell your doctor if you drink alcohol.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or if you have kidney disease, liver disease, or nerve problems (including diabetic neuropathy).
• Do not breastfeed during treatment with this medicine.
• This medicine may cause low blood sugar, when used with other diabetes medicine.
• This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Fever, chills, cough, runny or stuffy nose, sore throat, body aches
• Shaking, trembling, sweating, fast or pounding heartbeat, faintness or lightheadedness, hunger, confusion

If you notice these less serious side effects, talk with your doctor:

• Back or joint pain
• Diarrhea
• Dizziness
• Weight gain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024