Health Library

Insulin nph/regular (By injection)

Insulin Human Isophane (NPH) (IN-su-lin HUE-man EYE-soe-fane (NPH)), Insulin Human Regular (IN-su-lin HUE-man REG-yoo-lar)

Treats diabetes.

Brand Name(s):

HumuLIN 70/30, HumuLIN 70/30 Kwikpen, NovoLIN 70/30, NovoLIN 70/30 FlexPen, ReliOn NovoLIN 70/30 FlexPen, Relion Novolin 70/30

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. It is usually given in the stomach, thigh, or upper arm.
• You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
• Always double-check both the concentration (strength) of your insulin and your dose. Concentration and dose are not the same. The dose is how many units of insulin you will use. The concentration tells how many units of insulin are in each milliliter (mL), such as 100 units/mL (U-100), but this does not mean you will use 100 units at a time.
• Humulin 70/30 should be given at least 30 to 45 minutes before a meal.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• This medicine should be cloudy after mixing. Do not mix this medicine with any other insulin or with water.
• You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not use the exact same spot for each injection.
• Use a new needle and syringe each time you inject your medicine. If you use a syringe, use only the kind that is made for insulin injections. Some insulin must be given with a specific type of syringe or needle. Ask your pharmacist if you are not sure which one to use.
• Always check the label before use, to make sure you have the correct type of insulin. Do not change the brand, type, or concentration unless your doctor tells you to. If you use a pump or other device, make sure the insulin is made for that device.
• Gently shake or roll the vial or pen 10 times and then turn it upside down 10 times to mix the insulin.
• This medicine comes in different brands and forms. Follow the manufacturer's directions on how to store your specific insulin.
• Unopened medicine:
  • Vials: Store in the refrigerator. You may store the medicine at room temperature for 31 days. Protect from light. Do not freeze
  • Prefilled pens: Store in the refrigerator. You may store the medicine at room temperature for 10 days. Protect from light. Do not freeze
• Opened medicine:
  • Vials: Store in the refrigerator or at room temperature in a cool place, away from sunlight and heat. Use within 31 days.
  • Prefilled pens: Store at room temperature, away from direct heat and light. Do not refrigerate. Throw away any opened pen after 10 days.
• Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can change the amount of insulin you need to use and make it harder for you to control your diabetes. Tell your doctor about all other medicines that you are using.
• Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or heart disease (including heart failure).
• This medicine may cause the following problems:
  • Low blood sugar or low potassium levels in the blood
  • Fluid retention or heart failure (when used together with a thiazolidinedione [TZD] medicine)
• This medicine can cause low blood sugar. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
• Never share insulin pens or needles with anyone. Sharing these can pass hepatitis viruses, HIV, or other illnesses from one person to another.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Dry mouth, increased thirst, muscle cramps, nausea or vomiting, uneven heartbeat
• Rapid weight gain, swelling in your hands, ankles, or feet, trouble breathing, tiredness
• Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion

If you notice these less serious side effects, talk with your doctor:

• Redness, itching, swelling, or skin changes where the shot is given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024