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Gadobenate dimeglumine (By injection)

Gadobenate Dimeglumine (gad-oh-BEN-ate dye-MEG-loo-meen)

Used to help see images of your brain, spine, and other parts of your body during a magnetic resonance imaging (MRI) scan. This medicine is a gadolinium-based contrast agent (GBCA).

Brand Name(s):

Multihance

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. It is given just before you have an MRI scan.
• A nurse or other health provider will give you this medicine.
• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how gadobenate works. Tell your doctor if you are using cisplatin, daunorubicin, doxorubicin, etoposide, methotrexate, paclitaxel, tamoxifen, or vincristine.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, anemia or any other blood disorder, asthma, diabetes, heart disease, heart rhythm problems (including arrhythmia), high blood pressure, seizures, or a history of an allergic reaction to any contrast agent. Tell your doctor if you have any allergic respiratory diseases or Dubin-Johnson syndrome. Tell your doctor if you have ever received a GBCA.
• This medicine may cause the following problems:
  • Serious unwanted effects including brain problems (encephalopathy), death, coma, and seizures, when given intrathecally (injection given through the spinal canal)
  • Nephrogenic systemic fibrosis (NSF)
  • Acute kidney injury (AKI)
  • Injection site reactions
  • Hearth rhythm problems
• This medicine contains a metal called gadolinium, which can stay in your body (including the brain, bones, skin, and other organs) for a long time (several months to years). Talk to your doctor if you have concerns about this.
• Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Change in how much or how often you urinate, blood in your urine
• Cold feeling, seizures, tremors, or increased salivation
• Fast, slow, or pounding heartbeat
• Lightheadedness, dizziness, or fainting
• Muscle stiffness or weakness, stiff joints or trouble moving, or deep bone pain
• Numbness, tingling, or burning pain in your hands, arms, legs, or feet
• Skin rash, swelling, hardness, tightness, burning, itching, or red or dark patches

If you notice these less serious side effects, talk with your doctor:

• Headache, nausea
• Pain, burning, itching, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024