Health Library

Esomeprazole (By injection)

Esomeprazole (es-oh-MEP-ra-zole)

Treats gastroesophageal reflux disease (GERD) with erosive esophagitis (damaged esophagus). Lowers the risk of bleeding after endoscopy in patients with ulcers. This medicine is a proton pump inhibitor (PPI).

Brand Name(s):

NexIUM I.V.

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
• A nurse or other health provider will give you this medicine.
• Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use this medicine if you are also using it together with rilpivirine or other products containing rilpivirine.
• Some medicines can affect how esomeprazole works. Tell your doctor if you are using any of the following:
  • Atazanavir, cilostazol, citalopram, dasatinib, digoxin, erlotinib, itraconazole, ketoconazole, methotrexate, mycophenolate mofetil, nelfinavir, nilotinib, rifampin, ritonavir, saquinavir, St John's wort, tacrolimus, voriconazole
  • Blood thinner (including clopidogrel or warfarin)
  • Diuretic (water pill)
  • Iron supplements

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, stomach or bowel cancer, or osteoporosis.
• This medicine may cause the following problems:
  • Kidney problems, including acute tubulointerstitial nephritis
  • Increased risk of broken bones in the hip, wrist, or spine (more likely if received several times per day or longer than 1 year)
  • Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS)
  • Lupus
  • Fundic gland polyps (abnormal growth in the upper part of your stomach)
• This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
• Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, red skin rash
• Dry mouth, increased thirst, confusion, numbness and tingling around the mouth, fingertips, or feet
• Fever, swelling in your body, unusual weight gain, changes in how much or how often you urinate, blood in the urine
• Joint pain, rash on your cheeks or arms that gets worse in the sun
• Seizures, dizziness, fast or uneven heartbeat, muscle cramps or twitching
• Severe diarrhea that does not go away, stomach cramps or pain, nausea, vomiting, loss of appetite, weight loss
• Unusual bleeding, bruising, tiredness, or weakness

If you notice these less serious side effects, talk with your doctor:

• Constipation, stomach upset
• Headache
• Redness, pain, itching, swelling, or a lump under your skin where the needle is placed
• Trouble having an erection

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024