Methadone (By injection)
Methadone (METH-a-done)
Treats moderate to severe pain and opioid use disorder in patients who cannot take oral medicines.
Brand Name(s):
There may be other brand names for this medicine.When This Medicine Should Not Be Used:
This medicine is not right for everyone. You should not receive it if you had an allergic reaction to methadone, or if you have severe lung or breathing problems, or stomach or bowel blockage (including paralytic ileus).How to Use This Medicine:
Injectable
- A nurse or other health provider will give you this medicine in a medical facility. This medicine is given as a shot under your skin or into a muscle or a vein.
- An overdose can be life-threatening. Your doctor may give naloxone to treat an overdose. Naloxone is a medicine that temporarily reverses the effects of an overdose. If you have been prescribed naloxone, make sure household members know how to use this on you in the event of an overdose or suspected overdose. Emergency medical attention is still needed after naloxone is used because the reversal effects are only temporary.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines can affect how methadone works. Tell your doctor if you are using any of the following:
- Carbamazepine, cyclobenzaprine, desipramine, didanosine, erythromycin, fluconazole, fluvoxamine, ketoconazole, metaxalone, mirtazapine, phenobarbital, phenytoin, rifampin, ritonavir, sertraline, stavudine, St John's wort, telaprevir, tramadol, trazodone, voriconazole, or zidovudine
- Blood pressure medicine
- Diuretic (water pill)
- Hormone medicines
- Laxatives (stool softeners)
- MAO inhibitor (MAOI) within the past 14 days
- Medicine to treat depression, anxiety, or mental health illness
- Medicine to treat heart rhythm problems
- Medicine to treat HIV or AIDS
- Phenothiazine medicine
- Steroid medicine
- Triptan medicine to treat migraine headaches
- Do not drink alcohol while you are using this medicine.
- Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are also using buprenorphine, butorphanol, nalbuphine, pentazocine, a benzodiazepine, or a muscle relaxer.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, heart rhythm problems (including long QT syndrome), breathing or lung problems (including asthma, COPD, sleep apnea), gallbladder problems, low magnesium or potassium in the blood, pancreas problems, stomach or bowel problems, thyroid problems, or trouble urinating. Tell your doctor if you also have a history of head injury, brain tumors, seizures, depression, or alcohol or drug use disorder.
- This medicine may cause the following problems:
- High risk of overdose, which can lead to death
- Respiratory depression (serious breathing problem that can be life-threatening)
- Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)
- Heart rhythm problems
- Worsening of pain
- Serotonin syndrome (when used with certain medicines)
- Adrenal gland problems
- Low blood pressure
- This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.
- This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.
- Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
- This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.
- Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there
- Blue lips, fingernails, or skin
- Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, seizures, cold or clammy skin
- Fast, pounding, or uneven heartbeat
- Severe confusion, lightheadedness, dizziness, fainting
- Severe constipation, stomach pain, nausea, or vomiting
- Trouble breathing or slow breathing
If you notice these less serious side effects, talk with your doctor:
- Mild constipation, nausea, or vomiting
- Mild sleepiness or tiredness
- Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 9/6/2024
