Health Library

Milnacipran (By mouth)

Milnacipran (mil-NA-si-pran)

Treats fibromyalgia. This medicine is an SSNRI.

Brand Name(s):

Savella, Savella Titration Pack

When This Medicine Should Not Be Used:

How to Use This Medicine:

Tablet

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
• Missed dose: If you miss a dose, skip the missed dose and take your next dose at your regular scheduled time.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use this medicine if you have used an MAO inhibitor (MAOI) within the past 14 days. Do not take an MAOI for at least 5 days after stopping this medicine.
• Some medicines can affect how milnacipran works. Tell your doctor if you are using any of the following:
  • Buspirone, clomipramine, clonidine, digoxin, fentanyl, lithium, St John's wort, tramadol
  • Amphetamines
  • Blood thinner (including warfarin)
  • Diuretic (water pill)
  • Medicine to treat depression (including TCAs)
  • NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)
  • Triptan medicine to treat migraine headaches
  • Tryptophan supplement
  .
• Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, heart rhythm problems, high blood pressure, glaucoma, an enlarged prostate, or a history of painful or difficult urination. Tell your doctor if you have a history of seizures or if you drink alcohol.
• For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.
• This medicine may cause the following problems:
  • Serotonin syndrome (may be life-threatening when used with certain other medicines)
  • High blood pressure
  • Liver problems
  • Increased risk of bleeding problems (especially if used with a blood thinner or NSAIDs)
  • Sexual problems
• This medicine may make you drowsy or less alert. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
• Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your blood pressure and heart rate will also be monitored while you use this medicine.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Anxiety, restlessness, fever, sweating, muscle spasms, diarrhea, seeing or hearing things that are not there
• Blistering, peeling, red skin rash
• Confusion, weakness, and muscle twitching
• Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
• Eye pain, vision changes, seeing halos around lights
• Fast, pounding, or uneven heartbeat or pulse
• Increased energy, racing thoughts, reckless behavior, talking more than usual, trouble sleeping
• Loss in sexual ability, desire, drive, or performance, delayed or inability to have an orgasm, inability to have or keep an erection
• Seizures or tremors
• Thoughts of hurting yourself or others, unusual mood or behavior
• Unusual bleeding or bruising

If you notice these less serious side effects, talk with your doctor:

• Constipation
• Mild headache or dizziness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024