Health Library

Pazopanib (By mouth)

Pazopanib (paz-OH-pa-nib)

Treats advanced kidney cancer and soft tissue sarcoma.

Brand Name(s):

Votrient

When This Medicine Should Not Be Used:

How to Use This Medicine:

Tablet

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
• It is best to take this medicine on an empty stomach. Take this medicine at least 1 hour before or 2 hours after a meal.
• Swallow the tablet whole. Do not crush, break, or chew it.
• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
• Missed dose: If you miss a dose or forget to take your medicine and it is less than 12 hours until your next dose, skip that dose and take your next dose at the normal time. Do not use extra medicine to make up for a missed dose.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some foods and medicines can affect how pazopanib works. Tell your doctor if you are using any of the following:
  • Bevacizumab, clarithromycin, ketoconazole, lapatinib, pemetrexed, rifampin, ritonavir, simvastatin, topotecan
  • Medicine for heart rhythm problems
  • Stomach medicine (including esomeprazole)
• Take antacids several hours before or after you take pazopanib.
• Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

• This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Men and women should use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for at least 2 weeks after your last dose.
• Do not breastfeed while you are using this medicine and for 2 weeks after the last dose.
• Tell your doctor if you have kidney disease, liver disease (including Gilbert syndrome), heart disease, high blood pressure, lung disease, stomach or bowel problems, thyroid problems, or a history of heart rhythm problems (including QT prolongation), heart attack, or stroke. Tell your doctor if you had any bleeding problems in the last 6 months, including stomach or bowel bleeding.
• This medicine may cause the following problems:
  • Severe liver problems
  • Changes in heart rhythm, including QT prolongation, Torsades de pointes
  • Heart failure, high blood pressure, heart attack, or stroke
  • Bleeding problems
  • Increased risk of blood clots
  • Interstitial lung disease or pneumonitis, which may be life-threatening
  • Stomach or bowel problems (including perforation, fistula)
  • Reversible posterior leukoencephalopathy syndrome (RPLS)
  • High blood pressure
  • Hypothyroidism (underactive thyroid)
  • Kidney problems
  • Tumor lysis syndrome
  • Serious infections
• Tell any doctor who treats you that you are using this medicine. This medicine may affect the way your body heals from cuts and wounds. You may need to stop using it at least 7 days before you have surgery.
• Cancer medicines can cause diarrhea, nausea, or vomiting in most people, sometimes even after they receive medicine to prevent it.
• Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
• This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Bloody or black, tarry stools, vomiting of blood or material that looks like coffee grounds
• Chest pain that may spread to your arms, jaw, back, or neck, unusual sweating, faintness
• Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
• Fast, pounding, or uneven heartbeat, dizziness or lightheadedness
• Fever, chills, cough, sore throat, and body aches
• Numbness or weakness on one side of your body, pain in your lower leg, sudden or severe headache, problems with vision, speech, or walking, confusion, seizures
• Swelling in your hands, ankles, or feet, trouble breathing, tiredness

If you notice these less serious side effects, talk with your doctor:

• Change in skin or hair color, hair loss
• Change or loss of taste
• Mild nausea, vomiting, diarrhea
• Muscle, bone, or joint pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024