Health Library

Siltuximab (By injection)

Siltuximab (sil-TUX-i-mab)

Treats multicentric Castleman disease.

Brand Name(s):

Sylvant

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine must be given slowly, so the needle will have to stay in place at least 1 hour.
• A nurse or other health provider will give you this medicine.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how siltuximab works. Tell your doctor if you are using atorvastatin, cyclosporine, lovastatin, theophylline, a birth control pill, or blood thinner (including warfarin).
• This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant. It is not known if this medicine affects an unborn baby. You must use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for 3 months after the last dose.
• Tell your doctor if you are breastfeeding, or if you have stomach or bowel problems (including diverticulitis or ulcers) or any type of infection.
• This medicine may cause the following problems:
  • Increased risk of infection
  • Infusion reactions
  • Stomach or bowel perforation (tear or hole)
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Change in how much or how often you urinate
• Chest pain, trouble breathing, lightheadedness
• Fever, chills, cough, runny or stuffy nose, sore throat, body aches
• Rapid weight gain, swelling in your hands, ankles, or feet
• Severe stomach pain, red or black stools, vomiting blood or material that looks like coffee grounds
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Headache
• Sore mouth and throat

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024