Health Library

Letermovir (By injection)

Letermovir (let-ER-moe-vir)

Prevents cytomegalovirus (CMV) infection and disease.

Brand Name(s):

Prevymis

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine must be given slowly, so the needle will have to stay in place for over an hour.
• A nurse or other health provider will give you this medicine.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• You should not receive this medicine together with pimozide or ergot medicines.
• Do not use pitavastatin or simvastatin if you receive this medicine together with cyclosporine.
• Some medicines can affect how letermovir works. Tell your doctor if you are using any of the following:
  • Alfentanil, amiodarone, bosentan, fentanyl, midazolam, modafinil, nafcillin, phenytoin, quinidine, rifabutin, rifampin, sirolimus, tacrolimus, thioridazine, voriconazole, St John wort
  • Blood thinner medicine (including warfarin)
  • HIV medicine (including efavirenz, etravirine, nevirapine)
  • Medicine to lower cholesterol (including atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin)
  • Oral diabetes medicine (including glyburide, repaglinide, rosiglitazone)
  • Proton pump inhibitor (including omeprazole, pantoprazole)
  • Seizure medicine (including carbamazepine, phenobarbital, phenytoin)

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or liver disease.
• Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Fever, chills, cough, sore throat, body aches
• Rapid weight gain, swelling in your hands, ankles, or feet

If you notice these less serious side effects, talk with your doctor:

• Diarrhea, nausea, vomiting, stomach pain
• Headache
• Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
• Tiredness or weakness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024