Health Library

Selinexor (By mouth)

Selinexor (SEL-i-nex-or)

Treats cancer, including multiple myeloma and lymphoma.

Brand Name(s):

Xpovio

When This Medicine Should Not Be Used:

How to Use This Medicine:

Tablet

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Take this medicine at the same time each day.
• Swallow the tablet whole with water. Do not break, chew, crush, or divide it.
• You may also receive medicines to help prevent nausea and vomiting.
• Drink plenty of fluids to help prevent dehydration and eat enough calories to help prevent weight loss during treatment with this medicine.
• Missed dose: If you miss a dose or vomit after taking this medicine, do not take an extra dose. Take the next dose at the regular time.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how selinexor works. Tell your doctor if you are using other medicine that cause dizziness or mental changes.

Warnings While Using This Medicine:

• This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Use an effective form of birth control during treatment and for at least 1 week after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for at least 1 week after the last dose.
• Do not breastfeed during treatment and for at least 1 week after the last dose.
• Tell your doctor if you have stomach or bowel problems, bleeding problems, or any type of infection.
• This medicine may cause the following problems:
  • Serious infections
  • Brain or nerve problems
  • Eye problem, including cataracts
• This medicine may make you dizzy or confused. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
• Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
• Cancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.
• This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blurred vision, headache
• Confusion, weakness, muscle twitching
• Dizziness, fainting, loss of consciousness, seeing, hearing, or feeling things that are not there
• Fever, chills, cough, sore throat, runny or stuffy nose, body aches
• Numbness, tingling, or burning pain in your hands, arms, legs, or feet
• Severe nausea, vomiting, diarrhea, loss of appetite, or weight loss
• Stomach pain, flushed, dry skin, and fruit-like breath odor
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Change in taste
• Constipation
• Tiredness
• Trouble sleeping

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024