Health Library

Omeprazole/amoxicillin/rifabutin (By mouth)

Amoxicillin (a-mox-i-SIL-in), Omeprazole Magnesium (oh-MEP-ra-zole mag-NEE-zee-um), Rifabutin (rif-a-BUE-tin)

Treats H. pylori infection.

Brand Name(s):

Talicia

When This Medicine Should Not Be Used:

How to Use This Medicine:

Delayed Release Capsule

• Your doctor will tell you how much medicine to use. Do not use more than directed.
• Swallow the capsule whole with a full glass of water. Do not crush, chew, or open it.
• It is best to take this medicine with food or milk.
• Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.
• Missed dose: If you miss a dose and it is more than 4 hours until your next scheduled dose, take it as soon as possible, and then go back to your regular schedule. If you miss a dose and it is less than 4 hours until your next scheduled dose, skip the missed dose and take your next dose at the regular time. Do not use extra medicine to make up for a missed dose.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in its original container. Keep the bottle tightly closed.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use this medicine together with delavirdine, rilpivirine, or voriconazole.
• Some medicines can affect how this medicine works. Tell your doctor if you are using any of the following:
  • Allopurinol, citalopram, cilostazol, clopidogrel, cyclosporine, dasatinib, diazepam, digoxin, disulfiram, erlotinib, fluconazole, iron salts, itraconazole, ketoconazole, methotrexate, mycophenolate mofetil, nilotinib, phenytoin, posaconazole, probenecid, rifampin, St John's wort, tacrolimus
  • Birth control pills
  • Blood thinner (including warfarin)
  • Medicine to treat HIV infection (including amprenavir, atazanavir, fosamprenavir/ritonavir, indinavir, lopinavir/ritonavir, nelfinavir, saquinavir, saquinavir/ritonavir, ritonavir, tipranavir/ritonavir)
• Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine:

• Using this medicine while you are pregnant can harm your unborn baby. Use birth control pills together with another form of birth control (including condom, diaphragm, or contraceptive foam or jelly) to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, eye or vision problems, or lupus.
• This medicine may cause the following problems:
  • Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS)
  • Stomach or bowel problems, including drug-induced enterocolitis syndrome (DIES)
  • Kidney problems, including acute tubulointerstitial nephritis
  • Cutaneous or systemic lupus erythematosus
• This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
• This medicine may cause your skin, tears, saliva, sweat, urine, or bowel movements to turn a brownish-orange color. Your contact lenses could become permanently discolored.
• Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
• Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
• Call your doctor if your symptoms do not improve or if they get worse.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, red skin rash
• Blurred vision, change in vision
• Dry mouth, increased thirst, confusion, numbness and tingling around the mouth, fingertips, or feet
• Fever, swelling in the body, unusual weight gain, change in how much or how often you urinate, blood in the urine
• Itching of the vagina or genitals, thick, white vaginal discharge with mild or no odor
• Joint pain, rash on your cheeks or arms that gets worse in the sun
• Severe diarrhea that does not go away, stomach cramps or pain, nausea, vomiting, loss of appetite, weight loss
• Unusual bleeding, bruising, tiredness, or weakness

If you notice these less serious side effects, talk with your doctor:

• Headache
• Mild diarrhea, stomach upset
• Sore throat
• Trouble having an erection
• Vaginal itching or discharge

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024