Health Library

Crizanlizumab-tmca (By injection)

Crizanlizumab-tmca (kriz-an-LIZ-ue-mab - tmca)

Prevents vaso-occlusive crisis in patients with sickle cell disease.

Brand Name(s):

Adakveo

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be injected slowly, so your IV will need to stay in place for 30 minutes.
• A nurse or other health provider will give you this medicine.
• Your doctor may want you to take hydroxyurea while you are receiving this medicine.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how crizanlizumab-tmca works. Tell your doctor if you are using a steroid medicine.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding.
• This medicine may cause infusion-related reactions, which can be life-threatening and require medical attention.
• Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
• Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Back, joint, muscle, or body pain
• Chest pain or discomfort, confusion, headache, numbness or tingling in the face, arms, or legs, trouble walking or speaking
• Fever, chills, cough, sore throat, dizziness, diarrhea, nausea, vomiting, stomach pain, sweating, trouble breathing, tiredness

If you notice these less serious side effects, talk with your doctor:

• Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024