Drug Notes - Lonafarnib (By mouth) | Lima Memorial Health System

Lonafarnib (By mouth)

There may be other brand names for this medicine.

This medicine is not right for everyone. Do not use it if you had an allergic reaction to lonafarnib, or if you are pregnant.

Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
It is best to take this medicine with food or milk.
Swallow the capsule whole with water. Do not chew it.
If you cannot swallow the capsule whole, you may open it and mix the medicine with Ora Blend SF®, Ora-Plus®, orange juice, or applesauce. The mixture must be prepared fresh for each dose and taken within at least 10 minutes of mixing.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Missed dose: If you miss a dose and it is 8 hours or more until your next scheduled dose, take it as soon as possible, and then go back to your regular schedule. If you miss a dose and it is less than 8 hours until your next scheduled dose, skip the missed dose and take your next dose at the regular time.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Do not use this medicine together with atorvastatin, ketoconazole, lovastatin, rifampin, or simvastatin.
Do not use this medicine for 10 to 14 days before and 2 days after using midazolam.
Some foods and medicines can affect how lonafarnib works. Tell your doctor if you are using the following medicines:
- Dabigatran, digoxin, fexofenadine, loperamide, omeprazole, ritonavir
- Medicine that may cause heart rhythm problems
.
Do not eat grapefruit or Seville oranges while you are using this medicine. Do not mix this medicine with juice containing grapefruit or Seville oranges.

It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, bradycardia (slow heartbeat), low magnesium or potassium levels in the blood, eye or vision problems, or a history of heart rhythm problems.
This medicine may cause the following problems:
- Heart rhythm problems, including QT prolongation
- Kidney problems
- Eye or vision problems
This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
Keep all medicine out of the reach of children. Never share your medicine with anyone.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Blurred vision, nervousness, headache, slow, fast, pounding, or uneven heartbeat
Bone or muscle pain
Change in how much or how often you urinate
Confusion, weakness, muscle twitching, trouble breathing, numbness or tingling in your hands, feet, or lips
Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes
Dry mouth, increased thirst, muscle cramps, nausea or vomiting
Fainting, dizziness, lightheadedness
Fever, chills, cough, runny or stuffy nose, sore throat, body aches
Unusual bleeding, bruising, or weakness

Last Updated: 9/6/2024