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0-9

Tecovirimat (By injection)

Tecovirimat (tek-oh-VIR-i-mat)

Treats smallpox.

Brand Name(s):

Tpoxx

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to tecovirimat or if you have severe kidney disease.

How to Use This Medicine:

Injectable

Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. The medicine must be injected slowly, so your IV will need to stay in place for at least 6 hours.
A nurse or other health provider will give you this medicine.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Some medicines can affect how tecovirimat works. Tell your doctor if you are using midazolam, repaglinide, or phosphate binders (including calcium acetate, lanthanum carbonate, sevelamer, sucroferric oxyhydroxide).

Warnings While Using This Medicine:

Tell your doctor if you are pregnant, or if you have kidney disease, diabetes, or a weak immune system.
Do not breastfeed. You can spread smallpox virus to your baby through your breast milk.
This medicine may cause hypoglycemia (low blood sugar).
Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Shaking, trembling, sweating, fast or pounding heartbeat, faintness or lightheadedness, hunger, confusion

If you notice these less serious side effects, talk with your doctor:

Headache
Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024

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