Health Library

Donanemab-azbt (By injection)

Donanemab-azbt (doe-NAN-e-mab - azbt)

Treats Alzheimer disease.

Brand Name(s):

Kisunla

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. It must be given slowly, so the IV will have to remain in place for at least 30 minutes.
• A nurse or other health provider will give you this medicine.
• Your doctor will do magnetic resonance imaging (MRI) scans before the first treatment, and at certain times during treatment with this medicine.
• Your doctor may give you other medicines (including acetaminophen, allergy medicine, steroid medicine) before receiving this medicine to help prevent infusion-related reactions.
• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
• Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how donanemab-azbt works. Tell your doctor if you are using aspirin, an antiplatelet medicine, or a blood thinner.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant, breastfeeding, or if you have any other medical problems.
• This medicine may cause the following problems:
  • Amyloid related imaging abnormalities (ARIA), which can be seen as temporary swelling or bleeding in the brain
  • Infusion-related reactions
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blurred or changes in vision, confusion, dizziness, lightheadedness, headache, nausea, vomiting, seizures
• Fast or slow heartbeat, trouble breathing
• Fever, chills, body aches

If you notice these less serious side effects, talk with your doctor:

• Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024