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Arthritis

Joint inflammation; Joint degeneration

Arthritis is inflammation or degeneration of one or more joints. A joint is the area where 2 bones meet. There are more than 100 different types of arthritis.

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Causes

Arthritis involves the breakdown of structures of the joint, particularly cartilage. Normal cartilage protects a joint and allows it to move smoothly. Cartilage also absorbs shock when pressure is placed on the joint, such as when you walk. Without the normal amount of cartilage, the bones under the cartilage become damaged and rub together. This causes swelling (inflammation), and stiffness.

Other joint structures affected by arthritis include:

• The synovium
• The bone next to the joint
• Ligaments and tendons
• Sacs that may be fluid-filled next to bone, ligaments and tendons (bursae)

Joint inflammation and damage may result from:

• An autoimmune disease (the body's immune system mistakenly attacks healthy tissue)
• Broken bone
• General "wear and tear" on joints
• Infection, most often by bacteria or viruses
• Crystals such as uric acid or calcium pyrophosphate dihydrate

In most cases, the joint inflammation goes away after the cause goes away or is treated. Sometimes, it does not. When this happens, you have long-term (chronic) arthritis.

Arthritis may occur in people of any age and sex. Osteoarthritis, which is due to non-inflammatory processes and increases with age, is the most common type.

Other, more common types of inflammatory arthritis include:

• Ankylosing spondylitis
• Crystal arthritis, gout, calcium pyrophosphate deposition disease
• Juvenile rheumatoid arthritis (in children)
• Bacterial infections
• Psoriatic arthritis
• Reactive arthritis
• Rheumatoid arthritis (in adults)
• Scleroderma
• Systemic lupus erythematosus (SLE)

Symptoms

Arthritis causes joint pain, swelling, stiffness, and limited movement. Symptoms can include:

• Joint pain
• Joint swelling
• Joint deformity
• Reduced ability to move the joint
• Redness and warmth of the skin around a joint
• Joint stiffness, especially in the morning

Exams and Tests

The health care provider will perform a physical exam and ask about your medical history.

The physical exam may show:

• Fluid in or around a joint
• Warm, red, tender joints
• Difficulty moving a joint (called "limited range of motion")

Some types of arthritis may cause joint deformity. This may be a sign of severe, untreated rheumatoid arthritis or of osteoarthritis.

Blood tests and joint x-rays are often done to check for infection and other causes of arthritis.

The provider may also remove a sample of joint fluid with a needle and send it to a lab to be checked for inflammation crystals or infection.

Treatment

The underlying cause often cannot be cured. The goal of treatment is to:

• Reduce pain and inflammation
• Improve function
• Prevent further joint damage

LIFESTYLE CHANGES

Lifestyle changes are the preferred treatment for osteoarthritis and other types of joint swelling. Exercise can help relieve stiffness, reduce pain and fatigue, and improve muscle and bone strength. Your health care team can help you design an exercise program that is best for you.

Exercise programs may include:

• Low-impact aerobic activity (also called endurance exercise) such as walking
• Range of motion exercises for flexibility
• Strength training for muscle tone

Your provider may suggest physical therapy. This might include:

• Heat or ice.
• Splints or orthotics to support joints and help improve their position. This is often needed for rheumatoid arthritis.
• Water therapy.
• Massage.

Other things you can do include:

• Get plenty of sleep. Sleeping 8 to 10 hours a night and taking naps during the day can help you recover from a flare-up more quickly, and may even help prevent flare-ups.
• Avoid staying in one position for too long.
• Avoid positions or movements that place extra stress on your sore joints.
• Change your home to make activities easier. For example, install grab bars in the shower, the tub, and near the toilet.
• Try stress-reducing activities, such as meditation, yoga, or tai chi.
• Eat a healthy diet with plenty of fruits and vegetables, which contain important vitamins and minerals.
• Eat foods rich in omega-3 fatty acids, such as cold-water fish (salmon, mackerel, and herring), flaxseed, rapeseed (canola) oil, soybeans, soybean oil, pumpkin seeds, and walnuts.
• Avoid smoking and excessive alcohol consumption.
• Apply capsaicin cream over your painful joints. You may feel improvement after applying the cream for 3 to 7 days.
• Lose weight, if you are overweight. Weight loss can greatly improve joint pain in the legs and feet.
• Use a cane to reduce pain from hip, knee, ankle, or foot arthritis.

MEDICINES

Medicines may be prescribed along with lifestyle changes. All medicines have some risks. You should be closely followed by a provider when taking arthritis medicines, even ones you buy over-the-counter.

Over-the-counter medicines:

• Acetaminophen (Tylenol) is often the first medicine tried to reduce pain. Take up to 3,000 mg a day (2 extra-strength Tylenol every 8 hours). To prevent damage to your liver, do not take more than the recommended dose. Since multiple medicines are available without a prescription that also contain acetaminophen, you will need to include them in the 3,000 mg per day maximum. Also, avoid alcohol when taking acetaminophen.
• Aspirin, ibuprofen, or naproxen are nonsteroidal anti-inflammatory drugs (NSAIDs) that can relieve arthritis pain. However, they can carry risks when used for a long time. Possible side effects include heart attack, stroke, stomach ulcers, bleeding from the digestive tract, and kidney damage.

Depending on the type of arthritis, a number of other medicines may be prescribed:

• Corticosteroids ("steroids") help reduce inflammation. They may be injected into painful joints or given by mouth.
• Disease-modifying anti-rheumatic drugs (DMARDs) are used to treat autoimmune arthritis and SLE
• Biologics and kinase inhibitors are used for the treatment of autoimmune arthritis. They may be given by injection or by mouth.
• For gout, certain medicines to lower uric acid levels may be used.

It is very important to take your medicines as directed by your provider. If you are having problems doing so (for example, because of side effects), you should talk to your provider. Also make sure your provider knows about all the medicines you are taking, including vitamins and supplements bought without a prescription.

SURGERY AND OTHER TREATMENTS

In some cases, surgery may be done if other treatments have not worked and severe damage to a joint occurs. 

This may include:

• Joint replacement, such as a total knee joint replacement

Outlook (Prognosis)

A few arthritis-related disorders can be completely cured with proper treatment. Yet, many of these disorders become long-term (chronic) health problems but can often be well-controlled. Aggressive forms of some arthritic conditions may have significant effects on mobility and may lead to involvement of other body organs or systems.

Possible Complications

Complications of arthritis include:

• Long-term (chronic) pain
• Disability
• Difficulty performing daily activities

When to Contact a Medical Professional

Contact your provider if:

• Your joint pain persists beyond 3 days.
• You have severe unexplained joint pain.
• The affected joint is significantly swollen.
• You have a hard time moving the joint.
• Your skin around the joint is red or hot to the touch.
• You have a fever or have lost weight unintentionally.

Prevention

Early diagnosis and treatment can help prevent joint damage. If you have a family history of arthritis, tell your provider, even if you do not have joint pain.

Avoiding excessive, repeated motions may help protect you against osteoarthritis.

Related Information

References

Bykerk VP, Crow MK. Approach to the patient with rheumatic disease. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 236.

Fraenkel L, Bathon JM, England BR, et al. 2021 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol. 2021;73(7):1108-1123. PMID: 34101376 pubmed.ncbi.nlm.nih.gov/34101376/.

Hunter DJ. Osteoarthritis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 241.

Inman RD, Rahman P. Spondyloarthritis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 244.

McInnes IB. Rheumatoid arthritis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 243.

Review Date: 12/31/2023  

Reviewed By: Neil J. Gonter, MD, Assistant Professor of Medicine, Columbia University, NY and private practice specializing in Rheumatology at Rheumatology Associates of North Jersey, Teaneck, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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