Health Library

Dexrazoxane (By injection)

Dexrazoxane (dex-ray-ZOX-ane)

Helps prevent heart problems in women receiving doxorubicin for breast cancer. Also treats tissue damage caused by cancer medicines leaking from the blood vessels.

Brand Name(s):

Totect

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. It must be given slowly, so the needle will have to stay in place for 1 to 2 hours. If you are also taking doxorubicin: You will receive this medicine over 15 minutes before your doxorubicin treatment.
• If you are using an ice pack or any other cooling procedure at the affected area, you may have to remove it at least 15 minutes before receiving this medicine.
• You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines may affect how dexrazoxane works. Tell your doctor if you are also using other cancer treatments or topical dimethylsulfoxide (DMSO).

Warnings While Using This Medicine:

• This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment with this medicine and for at least 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 3 months after the last dose.
• Do not breastfeed during treatment with this medicine and for 2 weeks after your last dose.
• Tell your doctor if you have liver disease, kidney disease, or a blood disorder.
• If you are also taking doxorubicin: This medicine may not protect your heart completely. It is important to tell your doctor if you have any symptoms of heart problems, including trouble breathing, chest pain, lightheadedness, dizziness, or a fast or uneven heartbeat.
• This medicine can increase your risk for certain cancers, including leukemia. Talk to your doctor if you have questions or concerns.
• Talk with your doctor before receiving this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).
• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Fever, chills, cough, sore throat, body aches
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Diarrhea
• Nausea, vomiting
• Pain, burning, redness, or swelling under your skin where the needle is placed
• Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 9/6/2024